Metabolic Effects of a Hydrophobic Alginate Derivative and Tetrahydrolipstatin in Rats Fed a Diet Supplemented with Palm Fat and Cholesterol

The effects of octadecylamide alginic acid (amidated alginate) and tetrahydrolipstatin on serum hepatic cholesterol, the faecal output fat sterols, were investigated in rats. Amidated alginate is a sorbent lipids, an inhibitor pancreatic lipase. Rats fed diets containing cholesterol palm at 10 70 g/kg, respectively. Palm was provided by coconut meal. 40 g/kg diet significantly decreased total low-density lipoprotein lipids increased coprostanol. Tetrahydrolipstatin 300 mg/kg fat. intake feed not influenced; however, weight gains rats amidated lower than control group. Both modified fatty profile excreta lipids. Concentrations saturated acids those unsaturated increased. Despite different modes action, equally efficient removing dietary from body.